Characteristics
- INCI
- Madecassoside
- CAS
-
34540-22-2
This is the substance number in the Chemical Abstracts Service registry. The CAS number uniquely identifies a substance regardless of language, trade name, or synonyms.
- EC
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252-076-1
This is the substance number in the European chemical identification system (EC number), used in European regulatory databases including ECHA/CosIng.
- IUPAC
- O-6-Deoxy-Α-L-Mannopyranosyl-(1→4)-O-Β-D-Glucopyranosyl-(1→6)-Β-D-Glucopyranosyl (2Α,3Β,4Α,6Β)-2,3,6,23-Tetrahydroxyurs-12-En-28-Oate
- Functions
- antioxidant, skin conditioning
Who it's for
Description
One of the main biologically active components of the famous medicinal plant, Centella Asiatica, aka Gotu Kola. It has well established wound healing, skin-soothing and antioxidant activities.
There is also a study by La Roche Posay (belongs to L'Oreal) that examined the anti-aging effects of 5% Vitamin C combined with 0.1% Madecassoside. They mention that " Madecassoside is known to induce collagen expression and ⁄ or to modulate inflammatory mediators thus might prevent and correct some signs of aging." The surprisingly long, 6-month study observed "significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness,andskin hydration", but Vitamin C in itself is already an anti-aging superstar, so it is hard to know how much Madecassoside did.
Another promising property of Madecassoside is that it seems to inhibit UV-induced melanin synthesis (test formula with 0.05% MA, used twice a day on 23 volunteers for 8 weeks), making it a great active for hyperpigmentation-prone skin.
If that would not be enough, the French manufacturer (Seppic) also has encouraging in-vivo studies on the molecule. Used at 0.2%, Madecassoside reduces redness and peeling in skin with light atopic dermatitis as well as itching in psoriasis-prone skin.
If you are into Gotu Kola, read more here >>
Frequently Asked Questions about Madecassoside
What does madecassoside do for skin?
Is madecassoside good for sensitive or irritated skin?
How do you use madecassoside in skincare products?
Can madecassoside help with blemishes or acne-prone skin?
What types of products usually contain madecassoside?
Evidence & Research on Madecassoside
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1
Shen, Xueqing, et al. "Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica." Bioscience, biotechnology, and biochemistry 83.3 (2019): 561-568.Find in PubMed
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2
Jung, Eunsun, et al. "Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation." Molecules 18.12 (2013): 15724-15736.Find in PubMed
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3
Liu, Mei, et al. "Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice." Planta medica 74.08 (2008): 809-815.Find in PubMed
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4
Haftek, Marek, et al. "Clinical, biometric and structural evaluation of the long‐term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin." Experimental dermatology 17.11 (2008): 946-952.Find in PubMed
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5
Sasmita, Andrew Octavian, et al. "Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation." International journal of molecular medicine 41.5 (2018): 3033-3040.Find in PubMed
Products with Madecassoside (3 085 total)
Most often found in VT Cosmetics products (105 items)
