Characteristics
- INCI
- Zinc Pca
- CAS
-
68107-75-5, 15454-75-8
This is the substance number in the Chemical Abstracts Service registry. The CAS number uniquely identifies a substance regardless of language, trade name, or synonyms.
- EC
-
268-475-9, 239-473-5
This is the substance number in the European chemical identification system (EC number), used in European regulatory databases including ECHA/CosIng.
- IUPAC
- Proline, 5-Oxo-, Zinc Salt
- Functions
- humectant, skin conditioning
- EU Restr.
-
III/24
EU regulatory status: restricted use. The ingredient is permitted in EU cosmetics but its use and labelling are regulated.
More detail →
Who it's for
Description
When your skin is producing a bit too much shine and your pores seem to be staging a tiny rebellion, this is one of those ingredients that can look very appealing. Zinc PCA is basically a two-part team-up between zinc and PCA, with PCA standing for pyrrolidone carboxylic acid, one of the skin’s natural moisturizing factor components. So you get a combo that is trying to be both cleverly clarifying and not too drying, which is a nice change from some acne-fighting ingredients that can leave your face feeling like it has been through a desert walk.
The zinc part is the useful one for oily, blemish-prone skin. Zinc helps reduce sebum production and can make the environment less friendly for acne-related bacteria. PCA is not just there for decoration, either. It helps with skin hydration and can improve zinc’s bioavailability, which is a fancy way of saying it helps the zinc do its job better. In other words, the molecule is designed to be more than the sum of its parts.
There is some interesting data behind the hype. In one manufacturer-run in vivo test on real people, a 1% Zinc PCA formulation showed a statistically significant reduction in sebum after 28 days of use. Lab studies have also found antimicrobial activity against Cutibacterium acnes at concentrations around 0.1–0.25%, along with activity against other bacterial strains. That does not make it a miracle acne cure, of course, but it does explain why it often shows up in products aimed at shine control, congestion, and breakouts.
There is even a bit of bonus geekery: a 2011 study suggested that Zinc PCA could be interesting for anti-aging too, at least in lab conditions, by supporting type I collagen production. So while it is especially beloved by oily and acne-prone skin, it is not strictly a one-trick pony. If your skin wants fewer breakouts, a bit less grease, and a formulation that is usually kinder than many traditional acne actives, this one is definitely worth a look.
More detail
If you have oily, acne-prone skin, Zinc PCA is one of the actives to put on your "TO TRY" list.
It's a synergistic association of two great things: Zinc and L-PCA. The Zinc part is there to help normalize sebum production and limit the proliferation of evil acne-causing bacteria. L-PCA stands for pyrrolidone carboxylic acid and it's a key molecule in the skin that helps with processes of hydration and energy (it's actually an NMF, a natural moisturizing factor).
L-PCA is not only there to hydrate the skin, but it also helps to increase the efficacy and bioavailability of zinc. An in-vivo (done on real people) test done by the manufacturer shows that Zinc PCA reduces sebum production statistically significantly after 28 days of application (1% was used in the test), and in-vitro (made in the lab) measurements show that Zinc PCA has strong anti-microbial activity against P. acnes (between 0.1-0.25%) and other bacterial strains.
If that would not be enough there is also a 2011 research paper saying that based on in-vitro (made in the lab, not on real people) findings Zinc PCA might be a promising anti-aging active that helps with the production of type I collagen (and we all know more collagen = firmer skin).
All in all, definitely a goodie for oily, acne-prone skin.
Evidence & Research on Zinc Pca
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1
International Journal of Cosmetic Science, 11 August 2011, Zinc l-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis
Products with Zinc Pca (2 472 total)
Most often found in La Roche-Posay products (40 items)